Department of Biotechnology and Animal Science, NIU

:::
Wei-Jung Chen
Full-Time
Title Professor
Name Wei-Jung Chen
Email wjchen@niu.edu.tw
Office Tel No. 03-9357400 #7623(Office);7627(Lab)
Discipline Proteomics; Advanced Biochemistry; Organic Chemistry; Introduction to Biotechnology; Practices in Biochemistry
Research expertise 1. Multiple host-defense activities of novel antimicrobial peptides
2. Discovery of disease biomarkers using proteomics approaches
School Name Department Degree Duration
National Taiwan University Biochemistry and Molecular Biology Ph.D. 1999.08 ~ 2004.07
National Taiwan University Applied Microbiology M.S. 1994.08 ~ 1996.07
National Taiwan University Agricultural Chemistry B.S. 1990.08 ~ 1994.07
Dean of Academic Affairs (2015.08~)
Professor, Dept. Biotechnology and Animal Science, NIU (2014.08~)
Director, Center for Teaching and Learning Development, NIU (2014.02-2015.07)
Director, R&D Center for Biotech Products, NIU (2012.08-2015.07)
Deputy Dean, College of Bioresources, NIU (2012.08-2014.01)
Associate Professor, Dept. Biotechnology and Animal Science, NIU (2012.08-2014.07)
Director, Graduate Institute of Biotechnology, NIU (2010.08-2012.07)
Associate Professor, Graduate Institute of Biotechnology, NIU (2008.08-2012.07)
Assistant Professor, Graduate Institute of Biotechnology, NIU (2005.02-2008.07)
Honor Category Year Award Name Awarding Unit
Inside School Honor 2018
Outside School Honor 2018
Inside School Honor 2017
Inside School Honor 2017
Outside School Honor 2017
Outside School Honor 2016
Outside School Honor 2016
Outside School Honor 2016
Inside School Honor 2016
Outside School Honor 2016
Outside School Honor 2016
Inside School Honor 2015
Outside School Honor 2015
Outside School Honor 2015
Inside School Honor 2015
Outside School Honor 2015
Outside School Honor 2015
Inside School Honor 2014
Inside School Honor 2014
Outside School Honor 2014
Inside School Honor 2014
Outside School Honor 2014
Inside School Honor 2013
Inside School Honor 2013
Inside School Honor 2012
Inside School Honor 2012
Outside School Honor 2012
Outside School Honor 2012
Outside School Honor 2011
Inside School Honor 2011
Outside School Honor 2011
Outside School Honor 2011
Outside School Honor 2010
Outside School Honor 2010
Inside School Honor 2010
Inside School Honor 2009
Inside School Honor 2009
Inside School Honor 2008
Outside School Honor 2007
Inside School Honor 2005
Outside School Honor 2005
Outside School Honor 2005
Paper Title Journal Title Year Issue.No Vol.No
Isotypes of Autoantibodies Against Differentially Expressed Novel Malondialdehyde-Modified Peptide Adducts in Serum of Taiwanese Women with Rheumatoid Arthritis Journal of Proteomics 2018 170
A synthetic cationic antimicrobial peptide inhibits inflammatory response and the NLRP3 inflammasome by neutralizing LPS and ATP (in press) PLOS ONE 2017 7 12
2017 642
Hanatoxin Inserts into Phospholipid Membranes without Pore Formation BBA - Biomembranes (accepted) 2017 5 1859
Comparative proteome analysis reveals proteins involved in salt adaptation in Photobacterium damselae subsp. piscicida Journal of Basic Microbiology (in press) 2016 56
Novel antimicrobial peptides showed promising activity against multidrug resistant Salmonella enterica serovar Choleraesuis and its stress response mechanism revealed Journal of Applied Microbiology (in press) 2016 4 121
Effect of culture time on the growth curve and power performance in microbial fuel cell at a fixed amount of liquid culture (in press) International Journal of Green energy 2016 7 13
Comparative analysis of novel autoantibody isotypes against citrullinated-inter-alpha-trypsin inhibitor heavy chain 3 (ITIH3)542-556 peptide in serum from Taiwanese females with rheumatoid arthritis, primary Sjögren's syndrome and secondary Sjögren's syndrome in rheumatoid arthritis. Journal of Proteomics 2016 141
Guidelines for the use and interpretation of assays for monitoring autophagy (2nd edition) Autophagy 2016 1 12
CISD2 serves a novel role as a neuroinflammatory suppressor and curcumin increases CISD2 expression in spinal cord injuries Injury 2015 12 46
Analysis of differentially expressed novel post-translational modifications of plasma apolipoprotein E in Taiwanese females with breast cancer Journal of Proteomics 2015 126
Antimicrobial peptide GW-H1-induced apoptosis of human gastric cancer AGS cell line is enhanced by suppression of autophagy Molecular and Cellular Biochemistry 2015 400
Photobacterium damselae subsp. piscicida responds to antimicrobial peptides through phage-shock-protein A (PspA)-related extracytoplasmic stress response system Journal of Applied Microbiology 2015 1 118
Cystatin C in Cerebrospinal Fluid is Upregulated in Elderly Patients with Chronic Osteoarthritis Pain and Modulated via Matrix Metalloproteinase 9 Specific Pathway Clinical Journal of Pain 2014 30
Bovine lactoferricin B induces apoptosis of human gastric cancer AGS cell line by inhibition of autophagy in a late stage Journal of Dairy Science 2013 12 96
Application of aluminum-alloy mesh composite carbon cloth for the design of anode/cathode electrodes in Escherichia coli microbial fuel cell International Journal of Hydrogen Energy 2013 38
Comparative proteomics, network analysis and post-translational modification identification reveal differential profiles of plasma Con A-bound glycoprotein biomarkers in gastric cancer Journal of Proteomics 2013 83
Freshwater clam extract inhibits inflammatory responses in LPS-activated macrophages by reducing the activation of mitogen-activated protein kinase and NF-kB. Natural Product Communications 2012 7
Novel cationic antimicrobial peptide GW-H1 induced caspase-dependent apoptosis of hepatocellular carcinoma cell lines Peptides 2012 36
Influence of alanine uptake on Staphylococcus aureus surface charge and its susceptibility to two cationic antibacterial agents, nisin and low molecular weight chitosan. Food Chemistry 2012 135
Detection of gliadin in foods using a quartz crystal microbalance biosensor that incorporates gold nanoparticles. Journal of Agricultural and Food Chemistry 2012 60
Effect of different kinds of proton exchange membranes on the electricity generation of a microbial fuel Cell in Escherichia coli Journal of the Chinese Society of Mechanical Engineers 2012 33
The growth stimulating effect on queen bee larvae of histone deacetylase inhibitors. Journal of Agricultural and Food Chemistry 2012 60
Differential deoxyribonucleases are involved in bupivacaine-induced apoptosis of two canine mammary tumor cells Cell Biochemistry & Function (under review) 2011
Proteomic analysis reveals responsive proteins of Vibrio parahaemolyticus on exposure to cationic antimicrobial peptides Journal of Applied Microbiology (SCI) 2011 110
Interaction of cationic antimicrobial peptides with phospholipid vesicles and their antibacterial activity Peptides (SCI) 2010 31
IEF management: an investigation of salt interference and an algorithm for optimization Journal of Proteome Research(SCI) 2010 9
Influence of growth curve phase on electricity performance of microbial fuel cell by Escherichia coli International Journal of Hydrogen Energy (SCI) 2010 35
Assessment of the tumorigenesis and drug susceptibility of three new canine mammary tumor cell lines Research in Veterinary Science (SCI) 2010 88
Proteomic identification of membrane proteins regulating antimicrobial peptide resistance in Vibrio parahaemolyticus Journal of Applied Microbiology (SCI) 2010 108
Salt responsive outer membrane proteins of Vibrio anguillarum serotype O1 as revealed by comparative proteome analysis Journal of Applied Microbiology (SCI) 2009 106
Bupivacaine Induces Apoptosis Through Capase-dependent and Independent Pathways in Canine Mammary Tumor Cells Journal of Veterinary Medical Science (recommended accept)(SCI) 2009
Characterization of apoptosis induced by grouper iridovirus in two newly established cell lines from barramundi, Lates calcarifer (Bloch) Journal of Fish Diseases (SCI) 2008 31
Structure and function of deoxyribonuclease BioMedicine 2008 1
Design and synthesis of cationic antimicrobial peptides with improved activity and selectivity against Vibrio spp. International Journal of Antimicrobial Agents (SCI) 2008 32
Putative secondary active site of bovine pancreatic deoxyribonuclease I Protein and Peptide Letters (SCI) 2008 15
2-Nitro-5-thiosulfobenzoic acid as a novel inhibitor specific for deoxyribonuclease I Protein Journal (SCI) 2008 27
Construction and characterization of a bifunctional enzyme with deoxyribonuclease I and thioredoxin-like activities Biochemical and Biophysical Research Communications (SCI) 2007 356
Probing the catalytic mechanism of bovine pancreatic deoxyribonuclease I by chemical rescue Biochemical and Biophysical Research Communications (SCI) 2007 352
Structure and function of bovine pancreatic deoxyribonuclease Protein and Peptide Letters (SCI) 2006 13
Promotion of cell affinity of porous PLLA scaffolds by immobilization of RGD peptides via plasma treatment Macromolecular Bioscience (SCI) 2006 6
Deoxyribonuclease Ilan University Journal of Bioresources 2004 1
Involvement of the N- and C-terminal fragments of bovine pancreatic deoxyribonuclease in active protein folding Biochemistry (SCI) 2004 43
Biological functions of the disulfides in bovine pancreatic deoxyribonuclease 2004 13
Project Category Year Project Title Participartor Job Title Period Unit
Research Project 2019 2019.08 ~ 2021.07
Research Project 2019 2019.01 ~ 2019.12
Research Project 2018 2018.11 ~ 2019.07
Research Project 2018 優化設計抗菌胜肽以提升其對畜禽腸道病原菌之抗菌效力並以蛋白質體微陣列晶片解析其抗菌機制(1/3)(MOST 107-2313-B-197-005-MY3) 陳威戎 計畫主持人 2018.08 ~ 2021.07 科技部
Research Project 2018 評估陽離子抗菌胜肽對具抗藥性大腸癌細胞株之抗癌效力(MOST 107-2813-C-197-020-B) 陳威戎/尹若婷 計畫主持人 2018.07 ~ 2019.02 科技部
Research Project 2018 陽離子抗菌胜肽對多重抗藥性腸毒型大腸桿菌之抗菌效力(MOST 107-2813-C-197-022-B) 陳威戎/鄭宜榛 計畫主持人 2018.07 ~ 2019.02 科技部
Research Project 2018 新型水產機能性飼料添加物之研發及應用(2/2)(MOST 107-2321-B-006 -015-) 陳宗嶽陳威戎陳逸民陳永茂陳俊延 共同主持人(單一整合型計畫-子計畫五主持人) 2018.05 ~ 2019.04 科技部
Research Project 2017 以蛋白質體學方法探討精漿蛋白質與公豬無精症之關聯性 陳威戎 計畫主持人 2017.09 ~ 2018.01 東興婦產科診所
Research Project 2017 以蛋白質體學及次世代定序技術分析多重抗藥性豬霍亂沙門氏桿菌並探討其與新穎抗菌胜肽之交互作用機制(MOST 104-2313-B-197-002-MY3)(3/3) 陳威戎 計畫主持人 2017.08 ~ 2018.07 科技部
Research Project 2017 優化陽離子抗菌胜肽序列並提升其對大腸癌細胞之抗癌效力(MOST 106-2813-C-197-008-B) 陳威戎/柯品妤 計畫主持人 2017.07 ~ 2018.02 科技部
Research Project 2017 新型水產機能性飼料添加物之研發及應用(1/2)(MOST 106-3114-B-006 -002-) 陳宗嶽陳威戎陳逸民陳永茂陳俊延 共同主持人(單一整合型計畫-子計畫五主持人) 2017.05 ~ 2018.04 科技部
Research Project 2016 以蛋白質體學及次世代定序技術分析多重抗藥性豬霍亂沙門氏桿菌並探討其與新穎抗菌胜肽之交互作用機制(MOST 104-2313-B-197-002-MY3)(2/3) 陳威戎 計畫主持人 2016.08 ~ 2018.07 科技部
Research Project 2016 以三階式固態發酵開發機能性飼料並探討產製之抗菌胜肽對畜禽腸道病原菌之功效與作用機轉 鄭永祥; 陳威戎 共同主持人 2016.02 ~ 2017.03 科技部
Research Project 2015 以蛋白質體學方法探討精漿蛋白與公豬精子品質及受精能力之關聯性 陳威戎 計畫主持人 2015.09 ~ 2016.12 東興婦產科診所
Research Project 2015 以蛋白質體學及次世代定序技術分析多重抗藥性豬霍亂沙門氏桿菌並探討其與新穎抗菌胜肽之交互作用機制(MOST 104-2313-B-197-002-MY3)(1/3) 陳威戎 計畫主持人 2015.08 ~ 2018.07 科技部
Research Project 2015 新穎抗菌胜肽組合製劑之設計研發、抗菌效力測試暨表達系統建立(2/2) 陳威戎 計畫主持人 2015.08 ~ 2016.07 福又達生物科技股份有限公司
Research Project 2015 截短抗菌胜肽之設計研發及其對大腸癌細胞株之選擇性毒殺機制探討(MOST-104-2815-C-197-004-B) 陳威戎/藍靜雅_x0007_" _x0000__x0002__x0000__x0000__x0000__x0018__x0002__x0018_陳威戎林佳靜陳怡伶吳輔祐花國 計畫主持人 2015.07 ~ 2016.02 科技部
Research Project 2014 新穎抗菌胜肽組合製劑之設計研發、抗菌效力測試暨表達系統建立(1/2) 陳威戎 計畫主持人 2014.08 ~ 2015.07 福又達生物科技股份有限公司
Research Project 2014 合併施用Nisin與不同抗菌機制之陽離子抗菌胜肽探討協同抑制金黃色葡萄球菌活性之研究 林世斌; 陳威戎 共同主持人 2014.08 ~ 2016.07 科技部
Research Project 2013 新穎抗菌胜肽對多重抗藥性細菌之抗菌機制及宿主防禦胜肽之抗癌機制探討 陳威戎 計畫主持人 2013.08 ~ 2014.07 國科會
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計畫主持人 2013.01 ~ 2013.12 教育部資訊及科技教育司
Research Project 2012 新穎陽離子抗菌胜肽(宿主防禦胜肽)之抗菌、抗癌與抗發炎機制探討 陳威戎 計畫主持人 2012.08 ~ 2013.07 國科會
Research Project 2012 101年度轉譯醫學及農學人才培育先導型計畫-基因體及蛋白質體之臨床應用領域 陳威戎林佳靜吳輔祐郭村勇陳怡伶花國鋒楊瀅臻 計畫主持人 2012.01 ~ 2012.12 教育部顧問室
Research Project 2012 急性腎盂腎炎與腎結痂兒童尿中的先天免疫反應與發炎因子 陳威戎/蔡紫君 共同主持人 2012.01 ~ 2012.12 國立陽明大學附設醫院
Research Project 2011 新穎陽離子抗菌胜肽之多元宿主防禦功能探究-抗菌,抗癌,抗發炎與免疫調節活性 陳威戎 計畫主持人 2011.08 ~ 2012.07 國科會
Research Project 2011 以蛋白質體學方法蒐尋本土兒童逆流型腎炎之可能尿液生物標記_x001C_#_x001E__x001D__x001F_$ _x001D_!#%_x001D_)_x001D_,#3_x001D_7$8_x001D_9$:_x001D_#B$D#J_x001D_O#P_x001D_Q$R_x001D__x0001__x000C_ķ_x0000__x0000_ 陳威戎/鍾心語 計畫主持人 2011.07 ~ 2012.02 國科會
Research Project 2011 宜蘭地區服食三聚氰胺污染奶粉兒童的臨床腎臟表現與尿液蛋白質體學分析 陳威戎 共同主持人 2011.03 ~ 2011.12 國立陽明大學附設醫院
Research Project 2011 100年度轉譯醫學及農學人才培育先導型計畫-基因體及蛋白質體之臨床應用領域 陳威戎林佳靜郭村勇賴裕順陳怡伶花國鋒楊瀅臻 計畫主持人 2011.01 ~ 2011.12 教育部顧問室
Research Project 2011 大學跨學門科學人才培育銜接計畫-大腸桿菌生長週期中影響微生物燃料電池產電效率之關鍵因子探討 陳威戎 計畫主持人 2011.01 ~ 2011.12 教育部顧問室
Research Project 2010 以蛋白質體學方法探討海洋病原菌與抗菌胜肽之交互作用與抗性機制(3/3)(97-2311-B-197-001-MY3) 陳威戎 計畫主持人 2010.08 ~ 2011.07 國科會
Research Project 2010 99年度轉譯醫學及農學人才培育先導型計畫-基因體及蛋白質體之臨床應用領域 陳威戎 計畫主持人 2010.03 ~ 2010.12 教育部顧問室
Research Project 2010 重組抗菌胜肽產製平台之研發 陳威戎 計畫主持人 2010.01 ~ 2010.07 基龍米克斯生物科技有限公司
Research Project 2010 大學跨學門科學人才培育銜接計畫-解析大腸桿菌之電子傳遞機制以提升微生物燃料電池之產電效率 陳威戎 計畫主持人 2010.01 ~ 2010.12 教育部顧問室
Research Project 2009 以蛋白質體學方法探討海洋病原菌與抗菌胜肽之交互作用與抗性機制(2/3)(97-2311-B-197-001-MY3) 陳威戎 計畫主持人 2009.08 ~ 2010.07 國科會
Research Project 2009 蜂王乳主要蛋白質之蛋白質體分析與身份鑑定 陳威戎 計畫主持人 2009.02 ~ 2009.07 彥臣生技藥品股份有限公司
Research Project 2009 應用抗菌胜肽防治養殖魚類之細菌性感染(98農科-9.2.4-檢-B1(18)) 陳威戎 分項計畫主持人 2009.02 ~ 2009.12 農委會動植物防疫檢疫局
Research Project 2009 98年度生物及醫學科技人才培育先導型計畫-基因體與蛋白質體醫學領域 陳威戎 計畫主持人 2009.01 ~ 2009.12 教育部顧問室
Research Project 2009 大學跨學門科學人才培育銜接計畫-微生物燃料電池中微生物電子傳遞機制研究-以兼性厭氧菌為主 陳威戎 計畫主持人 2009.01 ~ 2009.12 教育部顧問室
Research Project 2008 以蛋白質體學方法探討海洋病原菌與抗菌胜肽之交互作用與抗性機制(1/3)(97-2311-B-197-001-MY3) 陳威戎 計畫主持人 2008.08 ~ 2011.07 國科會
Research Project 2008 大學跨學門科學人才培育銜接計畫-微生物燃料電池中微生物電子傳遞機制研究-以兼性厭氧菌為主 陳威戎 計畫主持人 2008.02 ~ 2008.12 教育部顧問室
Research Project 2008 97年度生物及醫學科技人才培育先導型計畫-基因體與蛋白質體醫學領域 陳威戎 計畫主持人 2008.01 ~ 2008.12 教育部顧問室
Research Project 2007 蝦肝胰臟核酸水解酵素之重組蛋白表現系統建立,催化機制探討與結構特性解析(96-2311-B-197-001) 陳威戎 計畫主持人 2007.08 ~ 2008.07 國科會
Research Project 2007 96年度生物及醫學科技人才培育先導型計畫-基因體與蛋白質體醫學領域 陳威戎 計畫主持人 2007.01 ~ 2007.12 教育部顧問室
Research Project 2006 甲型去氧核糖核酸水解酶之雙催化活性區機制,新穎氧化還原活性,及其參與細胞凋亡之可能機制探討(95-2311-B-197-003-) 陳威戎 計畫主持人 2006.08 ~ 2007.07 國科會
Research Project 2006 以蛋白質體學方法建立本土腎臟相關疾病之生物標記 許淑貞/陳威戎 計畫主持人 2006.07 ~ 2007.02 國科會
Research Project 2006 95年度尖端生物技術科技人才培育計畫-基因體與蛋白質體醫學領域 陳威戎 計畫主持人 2006.04 ~ 2006.12 教育部顧問室
Research Project 2005 甲型去氧核糖核酸水解酶之催化機制,基質切割模式與似硫氧化還原素活性之探討(94-2311-B-197-002-) 陳威戎 計畫主持人 2005.08 ~ 2006.07 國科會
Research Project 2005 具有抗微生物活性之功能性胜肽片段之設計開發及其於防治水產生物病害之應用(94-2317-B-197-001-)- 陳威戎 計畫主持人 2005.08 ~ 2006.12 國科會 (農業生技國家型計畫)
Research Project 2005 建立利用微生物與酵素促進有機肥料肥效釋放之關鍵技術(94-2317-B-197-002-) 陳威戎 共同主持人 2005.08 ~ 2006.12 國科會 (農業生技國家型計畫)
Publish Date Patent Title Patent Number Patent Country Authors
2015/10/01 大戟科植物活性物質及其應用 I504402 中華民國 陳威戎 / 郭村勇;楊瀅臻;陳威戎;花國鋒;周盈芳
2014/09/01 Use of histone deacetylase inhibitors in changing MRJP3 protein in royal jelly US 8,784,873 B2 美國 陳威戎 / 黃中洋;陳嘉南;陳威戎;黃偉展;紀俐伶
2014/08/01 一種人工合成胜肽用於製備具抗肝癌活性之藥物的用途(發明專利) I448297 中華民國 陳威戎 / 陳威戎;李俊宏;陳怡伶;林佳靜
2013/07/01 固態發酵冬蟲夏草(Cordyceps sinensis)飼料添加劑促進家禽性成熟的應用(發明專利) I401032 中華民國 陳威戎 / 鄭永祥;阮筱雯;林以琁;陳威戎;溫秋明
2012/08/01 組織蛋白去乙醯酶抑制劑於改變蜂王乳中MRJP3蛋白質的新穎用途(發明專利) I369951 中華民國 陳威戎 / 黃中洋;陳嘉南;陳威戎;黃偉展;紀俐伶
2011/06/01 新穎抗菌胜肽之設計合成技術平台之建立(技術移轉授權廠商:春泉生技開發股份有限公司/技轉金20萬元) 技術移轉 中華民國 陳威戎 / 陳威戎
2009/12/01 青蛋殼抗氧化成分萃取技術(技術移轉授權廠商:廣大利蛋品股份有限公司) 技術移轉 中華民國 陳威戎 / 林佳靜;汪世崇;郭村勇;黃振芳;江彰吉;陳銘正;陳威戎;陳怡伶