宜兰大学 生物技术与动物科学系

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 花国锋
专任教师
职称 教授
姓名 花国锋
电子邮件 kuofenghua@gmail.com
联络电话 03-9317626 (office); 03-9317630 (lab)
授课领域 分子免疫学
细胞讯息传递
发炎反应
研究专长 发炎之分子机转与抗发炎药物开发
活动服务 参与一览
国立阳明大学 医学生物技术研究所 博士 (2006)
辅仁大学 生物系 学士 (1999)
国立宜兰大学 生物技术与动物科学系 特聘教授(2018.08)
University of Tsukuba, Japan 访问学者 (2017)
国立宜兰大学 生物技术与动物科学系 教授(2015.08)
John Innes Centre, UK 访问学者 (2014)
国立宜兰大学 生物技术与动物科学系 副教授 (2012.08)
国立宜兰大学 生物技术研究所 副教授 (2011)
中央研究院 生物化学研究所 访问学者 (2011)
中国医药大学 药学系 兼任助理教授 (2010)
国立宜兰大学 生物技术研究所 助理教授 (2009)
中国医药大学 药物安全研究所 兼任助理教授 (2009)
中国医药大学 药物安全研究所 助理教授 (2008)
中央研究院 生物化学研究所 博士后研究 (2007)
国立阳明大学 生医光电工程研究所 博士后研究 (2006)
论文名称 期刊名称 年度 期数 卷数
Glucosamine inhibits IL-1β expression by preserving mitochondrial integrity and disrupting assembly of the NLRP3 inflammasome Scientific Reports 2019 in press
Compound K inhibits priming and mitochondria-associated activating signals of NLRP3 inflammasome in renal tubulointerstitial lesions Nephrology Dialysis Transplantation 2019 in press
Mechanistic insight into the attenuation of gouty inflammation by Taiwanese green propolis via inhibition of the NLRP3 inflammasome Journal of Cellular Physiology 2019 4 234
Synthesis of the trisaccharide repeating unit of capsular polysaccharide from Klebsiella pneumonia Tetrahedron Letters 2019 3 60
Ergosterol peroxide from marine fungus Phoma sp. induces ROS-dependent apoptosis and autophagy in human lung adenocarcinoma cells Scientific Reports 2018 1 8
Repositioning of the β-blocker carvedilol as a novel autophagy inducer that inhibits the NLRP3 inflammasome Frontiers in Immunology 2018 9
Antrodia cinnamomea Galactomannan Elicits Immunostimulatory Activity Through Toll-like receptor 4 International Journal of Biological Sciences 2018 10 14
Improvement of hyperglycemia in a murine model of insulin resistance and high glucose- and inflammasome-mediated IL-1β expressions in macrophages by silymarin Chemico-Biological Interactions 2018 290
Carboxylic and O-acetyl moieties are essential for the immunostimulatory activity of glucuronoxylomannan: a novel TLR4 specific immunostimulator from Auricularia auricula-judae Chemical Communications 2018 51 54
Affinity-driven Covalent Modulator of Glyceraldehyde-3-phosphate Dehydrogenase (GAPDH) Cascade Angew Chem Int Ed Engl 2018 24 57
A synthetic cationic antimicrobial peptide inhibits inflammatory response and the NLRP3 inflammasome by neutralizing LPS and ATP PLOS ONE 2017 7 12
A GalNAc/Gal-specific lectin from the sea mussel Crenomytilus grayanus modulates immune response in macrophages and in mice Scientific Reports 2017 1 7
IL-36 signaling facilitates the activation of NLRP3 inflammasome and IL-23/IL-17 axis in renal inflammation and fibrosis Journal of the American Society of Nephrology 2017 7 28
Lectin CGL from the sea mussel Crenomytilus grayanus induces Burkitt`s lymphoma cells death via interaction with surface glycan International Journal of Biological Macromolecules 2017 104
Galactomannan from Antrodia cinnamomea enhances the phagocytic activity of macrophages Organic Letters 2017 13 19
Corylin protects LPS-induced sepsis and attenuates LPS-induced inflammatory response Scientific Reports 2017 7
Neuroprotection by freshwater clam extract against the neurotoxin MPTP in C57BL/6 mice Neuroscience Letters 2017 642
NLRP3 inflammasome: Pathogenic role and potential therapeutic target for IgA nephropathy Scientific Reports 2017 7
SPAK plays a pathogenic role in IgA nephropathy through the activation of NF-κB/MAPKs signaling pathway Free Radical Biology & Medicine 2016 99
Hepatoprotective effect of wheat-based solid-state fermented Antrodia cinnamomea in carbon tetrachloride-induced liver injury in rat PLOS ONE 2016 4 11
A low toxicity synthetic cinnamaldehyde derivative ameliorates renal inflammation in mice by inhibiting NLRP3 inflammasome and its related signaling pathways Free Radical Biology and Medicine 2016 91
Citral alleviates an accelerated and severe lupus nephritis model by inhibiting the activation signal of NLRP3 inflammasome and enhancing Nrf2 activation Arthritis Research & Therapy 2015 17(1)
New HCRG-polypeptides of Kunitz-Type from the sea Anemone Heteractis crispa Marine Drugs 2015 10 13
Capsular polysaccharide is involved in NLRP3 inflammasome activation by Klebsiella pneumoniae serotype K1 Infection and Immunity 2015 83
Resveratrol inhibits NLRP3 inflammasome activation by preserving mitochondrial integrity and augmenting autophagy Journal of Cellular Physiology 2015 7 230
Composition, in vitro anti-inflammatory, antioxidant and antimicrobial activities of essential oils from leaf and twig parts of Cupressus cashmeriana Natural Product Communications 2015 8 10
Cyclooxygenase-2 regulates NLRP3 inflammasome-derived IL-1β production Journal of Cellular Physiology 2015 4 230
Peroxyauraptenol inhibits inflammation and NLRP3 inflammasome activation by inhibiting reactive oxygen species generation and preserving mitochondrial integrit Journal of Agricultural and Food Chemistry 2015 4 63
Essential oil from the heartwood of Taiwan fir ameliorates LPS-induced inflammatory response by inhibiting the activation of mitogen-activated protein kinase Natural Product Communications 2014 10 9
Essential oil from leaves of Liquidambar formosana ameliorates inflammatory response in lipopolysaccharide-activated mouse macrophages Natural Product Communications 2014 6 9
Osthole improves an accelerated focal segmental glomerulosclerosis model in early stage by activating Nrf2 antioxidant pathway and subsequent inhibition of NF-κB-mediated COX-2 expression and apoptosis Free Radical Biology & Medicine 2014 73C
Thrombomodulin domain 1 ameliorates diabetic nephropathy in mice via anti-NF-κB/NLRP3 inflammasome-mediated inflammation, enhancement of NRF2 antioxidant activity and inhibition of apoptosis Diabetologia 2014 57(2)
3,4-Dihydroxytoluene, a metabolite of rutin, inhibits inflammatory responses in lipopolysaccharide-activated macrophages by reducing the activation of NF-κB signaling BMC Complementary and Alternative Medicine 2014 14(1)
Osthole mitigates progressive IgA nephropathy by inhibiting reactive oxygen species generation and NF-kB/NLRP3 pathway PLoS ONE 2013 8(10)
Polyenylpyrrole derivatives inhibit NLRP3 inflammasome activation and inflammatory mediator expression through reduction of reactive oxygen species production and mitogen-activated protein kinase activation PLoS ONE 2013 8(10)
Bamboo vinegar decreases inflammatory mediator expression and NLRP3 inflammasome activation by inhibiting reactive oxygen species generation and protein kinase C-alpha/delta activation PLoS ONE 2013 8(10)
Citral is renoprotective for focal segmental glomerulosclerosis by inhibiting oxidative stress and apoptosis and activating Nrf2 pathway in mice PLoS ONE 2013 8(9)
Generation of reactive oxygen species by polyenylpyrroles derivatives causes DNA damage leading to G2/M arrest and apoptosis in human oral squamous cell carcinoma cells PLoS ONE 2013 8(6)
Antroquinonol mitigates accelerated and progressive IgA nephropathy model in mice via activating NrF2 pathway, and inhibiting T cells and NLRP3 inflammasome Free Radic Biol Med 2013 61C
Lipopolysaccharide/adenosine triphosphate-mediated signal transduction in the regulation of NLRP3 protein expression and caspase-1-mediated interleukin-1β secretion Inflammation Research 2013 62(1)
Freshwater Clam Extract Inhibits Inflammatory Responses in LPS-activated Macrophages by Reducing the Activation of Mitogen-activated Protein Kinases and NF-κB Natural Product Communications 2012 7(11)
High glucose increases nitric oxide generation in lipopolysaccharide-activated macrophages by enhancing activity of protein kinase C-alpha/delta and NF-kB Inflammation Research 2012 61(10)
Composition and Antipathogenic Activities of the Twig Essential Oil of Chamaecyparis formosensis from Taiwan Natural Product Communications 2012 7(7)
Oligosaccharide and Peptidoglycan of Ganoderma lucidum Activate the Immune Response in Human Mononuclear Cells Journal of Agricultural and Food Chemistry 2012 60(11)
Honokiol inhibits LPS-induced maturation and inflammatory response of human monocyte-derived dendritic cells Journal of Cellular Physiology 2011 226(9)
Epigallocatechin-3-gallate prevents lupus nephritis development in mice via enhancing the Nrf2 antioxidant pathway and inhibiting NLRP3 inflammasome activation Free Radical Biology & Medicine 2011 51(3)
Structure and immunological characterization of the capsular polysaccharide of a pyrogenic liver abscess Klebsiella pneumoniae: activation of macrophages through Toll-like receptor 4 Journal of Biological Chemistry 2011 286(24)
A novel exopolysaccharide from the biofilm of Thermus aquaticus YT-1 induces the immune response through Toll-like receptor 2 Journal of Biological Chemistry 2011 286(20)
Synthesis and biological evaluation of polyenylpyrrole derivatives as anti-cancer agents acting through caspases-dependent apoptosis Journal of Medicinal Chemistry 2010 53(22)
Osthole regulates inflammatory mediator expression through modulating NF-kB, mitogen-activated protein kinases, protein kinase C, and reactive oxygen species Journal of Agricultural and Food Chemistry 2010 58(19)
Immunostimulatory bioactivity of algal polysaccharides from Chlorella pyrenoidosa activates macrophages via Toll-like receptor 4 Journal of Agricultural and Food Chemistry 2010 58(2)
Binding and cleavage of E. coli Hua by the E. coli Lon Biophysical Journal 2010 98(1)
Cytomic screening of immuno-modulating activity compounds from Calocedrus formosana Combinatorial Chemistry & High Throughput Screening 2008 11(10)
Polysaccharides from Dioscorea batatas induce TNFa secretion via Toll-like receptor 4 mediated protein kinase signaling pathways Journal of Agricultural and Food Chemistry 2008 56(21)
Cyclopeptides with anti-inflammatory activity from seeds of Annona montana Journal of Natural Products 2008 71(8)
TLR-independent induction of human monocyte IL-1 by phosphoglycolipids from thermophilic bacteria Glycoconjugate Journal 2008 25(5)
Heme oxygenase-1 mediates the anti-inflammatory effect of curcumin within LPS-stimulated human monocytes Journal of Cellular Physiology 2008 215(3)
Reishi immuno-modulation protein induces interleukin-2 expression via protein kinase-dependent signaling pathways within human T Cells Journal of Cellular Physiology 2008 215(1)
New cyclic peptides from the seeds of Annona squamosa L. and their anti-inflammatory activities Journal of Agricultural and Food Chemistry 2008 56(2)
Cinnamaldehyde inhibits pro-inflammatory cytokines secretion from monocytes/macrophages through suppression of intracellular signaling Food and Chemical Toxicology 2008 46(1)
The interaction of lipopolysaccharide with membrane receptors on macrophages pre-treated with extract of reishi polysaccharides measured by optical tweezers Optical Express 2007 15(17)
Ganoderma lucidum polysaccharides enhance CD14 endocytosis of LPS and promote TLR4 signal transduction of cytokine expression Journal of Cellular Physiology 2007 212(2)
LTA and LPS mediated activation of protein kinases in the regulation of inflammatory cytokines expression in macrophages Clinica Chimica Acta 2006 (1-2)
Bioactivity assay of extracts from Calocedrus macrolepis var. formosana bark Bioresource Technology 2006 97(18)
Alkali-soluble polysaccharides of Rhizoclonium riparium alga induce IL-1 gene expression via protein kinase signaling pathways Journal of Agricultural and Food Chemistry 2006 54
Study on the anti-inflammatory activity of methanol extract from seagrass Zostera japonica Journal of Agricultural and Food Chemistry 2006 54
Study on the antiinflammatory activity of essential oil from leaves of Cinnamomum osmophloeum Journal of Agricultural and Food Chemistry 2005 53
Anti-inflammatory Activity of sugiol, a diterpene isolated from Calocedrus formosana bark Planta Medica 2005 71
Extract of reishi polysaccharides induces cytokine expression via toll-like receptor 4-modulated protein kinase signaling pathways Journal of Immunology 2004 173
Ligands of macrophage scavenger receptor induce cytokine expression via differential modulation of protein kinase signaling pathways Journal of Biological Chemistry 2001 276
计画类别 年度 计画名称 参与人 职称/担任之工作 计画期间 补助/委讬或合作机构
研究计画 2016 验证人蔘皂苷对亨廷顿舞蹈症预防与改善之功效 花国锋 计画主持人 2016.10 ~ 2017.09 汇德生物科技股份有限公司
研究计画 2016 利用NLRP3发炎体为主之疾病专一性分析平台验证人蔘皂苷对慢性肾脏病 花国锋 计画主持人 2016.08 ~ 2019.07 科技部
研究计画 2016 利用NLRP3发炎体为主之疾病专一性分析平台验证人蔘皂苷对慢性肾脏病 (延揽博士后研究人才) 花国锋 计画主持人 2016.08 ~ 2019.07 科技部
研究计画 2016 IgA肾炎小鼠的肾脏白血球侵润与细胞激素分泌 花国锋 计画主持人 2016.07 ~ 2016.12 财团法人工业技术研究院
研究计画 2016 学界协助中小企业科技关怀跨域整合计画-评估固态发酵培养牛樟芝产品应用于预防动脉硬化的可能性 花国锋 计画主持人 2016.05 ~ 2016.10 经济部
研究计画 2016 台湾-英国 双边研究计画: 建置一台英双方研究O-linked N-乙醯葡萄糖胺修饰蛋白调控NLRP3发炎体之整合型平台 花国锋 计画主持人 2016.04 ~ 2018.03 科技部
研究计画 2015 学界协助中小企业科技关怀跨域整合计画-探讨固态发酵培养牛樟芝产品预防与改善痛风的效果 花国锋 计画主持人 2015.05 ~ 2015.10 经济部
研究计画 2015 验证人蔘皂苷对痛风预防与改善之效果 花国锋 计画主持人 2015.05 ~ 2016.04 汇德生物科技股份有限公司
研究计画 2015 中小企业即时技术辅导计画-人蔘皂甙衍生物毒性与活性测试 花国锋 计画主持人 2015.04 ~ 2015.09 经济部
研究计画 2014 Synthesis of Some Carbohydrate Analogs as Potential Immunomodulating Agents 花国锋 计画主持人 2014.08 ~ 2017.07 新加坡大学与中央研究院
研究计画 2014 人蔘皂苷免疫调节活性试验 花国锋 计画主持人 2014.05 ~ 2015.04 汇德生物科技股份有限公司
研究计画 2014 学界协助中小企业科技关怀计画-牛樟芝多醣免疫调节功能测试 花国锋 计画主持人 2014.05 ~ 2015.10 经济部
研究计画 2014 学界协助中小企业科技关怀计画-人蔘皂苷之免疫调节活性测试 花国锋 计画主持人 2014.05 ~ 2014.10 经济部
研究计画 2014 台湾-俄罗斯 国际合作计画: 海洋天然物医药保健产品开发之合作交流平台 花国锋 计画主持人 2014.01 ~ 2016.12 科技部
研究计画 2013 竹醋液与其活性成分在发炎与代谢相关疾病预防及改善之应用 花国锋 计画主持人 2013.08 ~ 2016.07 国家科学委员会
研究计画 2012 新颖阳离子抗菌胜肽(宿主防御胜肽)之抗菌、抗癌与抗发炎机制探讨 花国锋 共同主持人 2012.08 ~ 2013.07 国家科学委员会
研究计画 2011 开发肉桂醛为预防发炎之保健产品与治疗发炎相关疾病之辅助制剂 花国锋 计画主持人 2011.08 ~ 2012.07 国家科学委员会
研究计画 2009 肝脓疡性克雷伯氏肺炎杆菌荚膜多醣体结构与功能性分析(延揽博士后研究人才) 花国锋 计画主持人 2009.08 ~ 2010.07 国家科学委员会
研究计画 2009 叶黄素对雄性小鼠生殖功能损伤模式之免疫调节作用机制 花国锋 共同主持人 2009.08 ~ 2012.07 国家科学委员会
研究计画 2009 肝脓疡性克雷伯氏肺炎杆菌荚膜多醣体结构与功能性分析 花国锋 计画主持人 2009.02 ~ 2010.07 国家科学委员会
研究计画 2007 开发藻类资源作为生质酒精 花国锋 共同主持人 2007.08 ~ 2010.07 国家科学委员会
发表日期 专利名称 专利编号 专利国别 作者
2018/12/03 Use of ginsenoside M1 for treating IgA nephropathy 领证中 美国 花国锋, 陈安, 贾淑敏, 理昱杰, 理筱龙, 许婉涵
2018/10/03 Use of ginsenoside M1 for preventing or treating gout 10,124,017 美国 花国锋, 理昱杰, 理筱龙
2018/10/03 Use of ginsenoside M1 for preventing or treating silicosis 10,130,647 美国 花国锋, 花国锋, 理昱杰
2018/12/03 Use of ginsenoside M1 for treating lupus nephritis 9,844,560 美国 花国锋, 陈安, 贾淑敏, 理昱杰, 理筱龙
2018/12/03 Use of ginsenoside M1 for treating lupus nephritis 3137089 欧盟 花国锋, 陈安, 贾淑敏, 理昱杰, 理筱龙, 许婉涵
2018/12/03 Use of ginsenoside M1 for treating IgA nephropathy 3137079 欧盟 花国锋, 陈安, 贾淑敏, 理昱杰, 理筱龙, 许婉涵
2018/08/03 Use of ginsenoside M1 for treating IgA nephropathy 602015018101.8 德国 花国锋, 陈安, 贾淑敏, 理昱杰, 理筱龙, 许婉涵
2016/07/12 羟基肉桂醛糖苷衍生物用于制备治疗肾丝球肾炎之组合物的用途 (中华民国专利) I 556821 中华民国 花国锋 / 花国锋、陈安、贾淑敏、陈水田、赵国评
2016/06/03 Use of polyenylpyrrole derivatives for treating inflammation (美国专利) US 9,475,789 B2 美国 花国锋 / 花国锋、理昱杰
2016/06/03 Use of osthole for treating focal segmental glomerulosclerosis (美国专利) US 9,393,226 B2 美国 花国锋 / 花国锋、陈安、贾淑敏、赵国评、杨顺闵
2015/11/12 蛇床子素用于制备治疗局部肾丝球硬化症之组合物的用途 (中华民国专利) I 544921 中华民国 花国锋 / 花国锋、陈安、贾淑敏、赵国评、杨顺闵
2015/10/03 Use of hydroxylcinnamaldehyde glycoside derivatives for manufacturing composition for treating glomerulosclerosis (美国专利) US 9,321,795 B2 美国 花国锋 / 花国锋、陈安、贾淑敏、陈水田、赵国评
2015/08/12 大戟科植物活性物质及其应用 (中华民国专利) I504402 中华民国 花国锋 / 郭村勇、杨滢臻、陈威戎,、花国锋、周盈芳
2015/05/12 木焦油醇用于抑制细胞之NLRP3复合发炎体活化及表现之用途 (中华民国专利) I498114 中华民国 花国锋 / 花国锋、陈安、贾淑敏、张嘉铭、蔡咏蓁
2015/02/12 柠檬醛用于制备治疗局部肾丝球硬化症之药物的用途 (中华民国专利) 发明第I463979号 中华民国 花国锋 / 花国锋、陈安、贾淑敏、赵国评、张温良、华国媛
2014/12/12 Use of citral for treating focal segmental glomerulosclerosis (美国专利) US 8,993,637 B2 美国 花国锋 / 花国锋、陈安、贾淑敏、赵国评、张温良、华国媛
2014/06/12 竹醋液及其活性成​分对抗氧化压力及发炎​相关疾病之应用 (中华民国专利) 发明第I 439277号 中华民国 花国锋 / 花国锋、陈安、贾淑敏、张嘉铭、蔡咏蓁
2013/08/12 Use of bamboo vinegar for treating inflammation (美国专利) US 8,518,461 B2 美国 花国锋 / 花国锋、陈安、贾淑敏、张嘉铭、蔡咏蓁
2010/03/12 Methods and compositions associated with administration of an extract of Ganoderma Lucidum (美国专利) US 7,687,064 B2 美国 花国锋 / 花国锋、许先业、翁启惠