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專任教師

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  • 職稱
    特聘教授
  • 姓名
    花國鋒
  • 電子郵件
  • 聯絡電話
    (03)9357400#7626
  • 授課領域
    醣生物學特論; 生物化學實驗 一; 細胞訊息傳遞; 專題討論 四; 發炎體與疾病; 生物化學實驗 二; 分子免疫學; 生物技術研究法 一; 基因體操作技術; 保健產品專題討論 一; 專題討論 二; 高等分子免疫學; 專題討論 一; 保健產品之分子免疫評估方法; 專題討論 三; 抗發炎活性分析平台與應用; 高等生物技術 一; 生技產學合作交流講座; 高等生物技術 二; 高等分子生物學 一; 抗發炎分析平台與應用; 高等分子生物學 二; 神經保護製劑與抗癌藥物開發; 生物技術與動物科學專論 二; 生物技術與動物科學專論 一
  • 研究專長
    多醣免疫調節活性分析; 天然物抗發炎活性分析; 合成藥物抗癌活性分析; NLRP3 inflammasome
學校 主修 學位 國別
國立陽明大學 醫學生物技術研究所 博士 中華民國
輔仁大學 生物系 學士 中華民國
服務機關 服務部門 職稱 起訖年月
Frontiers in Immunology Special Issue: NLRP3 inflammasome: regulatory mechanisms, role in health and disease, and therapeutic potential Guest Editor 2020.02~
國立宜蘭大學 研究發展處 研發長 2020.02~
International Journal of Molecular Sciences Special Issue: Inflammasome Guest Editor 2019.09~
Scientific Reports Scientific Reports Editor 2019.06~
國立宜蘭大學 生物技術與動物科學系 特聘教授 2018.08~
日本 University of Tsukuba Faculty of Medicine 訪問學者 2016
國立宜蘭大學 生物技術與動物科學系 教授 2015.08~2018.07
英國 The John Innes Centre Department of Biological Chemistry 訪問學者 2014
國立宜蘭大學 生物技術與動物科學系 副教授 2012.08~2015.07
國立宜蘭大學 生物技術研究所 副教授 2011.08~2012.07
國立宜蘭大學 生物技術研究所 助理教授 2009.08~2011.07
中國醫藥大學 藥物安全研究所 助理教授 2008.08~2009.07
類別 獲獎日期 名稱 國別 頒獎單位 獎助金額
校內 2020/07/28 109年度科技部大專校院研究獎勵 中華民國 科技部 154800
校內 2020/04/24 109年度產學合作績優教師 中華民國 研發處 50000
校內 2019/08/08 108年度科技部大專校院研究獎勵 中華民國 科技部 114000
校內 2018/08/14 107年度科技部大專校院研究獎勵 中華民國 科技部 106800
校內 2017/12/06 106年度研究績優獎 中華民國 研發處 80000
校內 2017/09/25 106年度大專校院獎勵特殊優秀人才 中華民國 科技部 103800
校內 2015/08/31 104年度大專校院獎勵特殊優秀人才 中華民國 科技部 120240
校內 2013/09/28 102年度研究績優獎 中華民國 國立宜蘭大學 80000
校內 2013/09/17 102學年度院級研究績優教師 中華民國 生物資源學院 12000
校內 2013/09/17 生資學院研究績優教師 中華民國 生資學院
校內 2012/07/30 101年度大專校院獎勵特殊優秀人才 中華民國 行政院國家科學委員會 134256
校內 2011/08/15 100年度大專校院獎勵特殊優秀人才 中華民國 行政院國家科學委員會 130200
實驗室名稱 實驗室網站連結
發炎反應研究室
年度 篇名 期刊等級 期刊名稱 第一作者 共同作者 卷期 起始頁 結束頁 總頁數 語言 相關網址
2020 Accelerated, severe lupus nephritis benefits from treatment with honokiol by immunoregulation and differentially regulating NF-κB/NLRP3 inflammasome and sirtuin 1/autophagy axis SCI The FASEB Journal Shin-Ruen Yang Wan-Han Hsu, Chung-Yao Wu, Hung-Sheng Shang, Feng-Cheng Liu, Ann Chen, Kuo-Feng Hua*, Shuk-Man Ka* in press 0 0 0
2020 Compound K inhibits priming and mitochondria-associated activating signals of NLRP3 inflammasome in renal tubulointerstitial lesions SCI Nephrology Dialysis Transplantation Wan-Han Hsu Kuo-Feng Hua, Li-Heng Tuan, Yu-Ling Tsai, Lichieh Julie Chu, Yu-Chieh Lee, Wei-Ting Wong, Sheau-Long Lee, Jenn-Haung Lai, Ching-Liang Chu, Ling-Jun Ho, Hsiao-Wen Chiu, Yu-Juei Hsu, Shuk-Man Ka, Ann Chen 35(1) 74 85
2020 Critical role for the NLRP3 inflammasome in mediating IL-1β production in Shigella sonnei-infected macrophages SCI Frontiers in Immunology Lan-Hui Li Tzu-Ling Chen, Hsiao-Wen Chiu, Chung-Hua Hsu, Chien-Chun Wang, Tzu-Ting Tai, Tz-Chuen Ju, Fang-Hsin Chen, Oleg V. Chernikov, Wen-Chiuan Tsai, Kuo-Feng Hua 11 1115 0 0
2020 Eucalyptus essential oils inhibit the lipopolysaccharide-induced inflammatory response in RAW264.7 macrophages through reducing MAPK and NF-κB pathways SCI BMC Complementary Medicine and Therapies Chen-Lung Ho Lan-Hui Li, Yueh-Chun Weng, Kuo-Feng Hua, Tz-Chuen Ju 20 200 0 0
2020 H-Phosphonate Synthesis and Biological Evaluation of an Immuno-modulatory Phosphoglycolipid from Thermophilic Bacteria SCI Organic Letters Chin Heng Gan Wijaya Hadhi, Lan-Hui Li, Chih-Feng Wei, Yi-Jen Peng, Shih-Hsiung Wu, Kuo-Feng Hua, Yulin Lam 22(7) 2569 2573 0
2020 IgA nephropathy benefits from compound K treatment by inhibiting NF-κB/NLRP3 inflammasome and enhancing autophagy and SIRT1 SCI Journal of Immunology Chung-Yao Wu Kuo-Feng Hua, Wan-Han Hsu, Yusuke Suzuki, Lichieh Julie Chu, Yu-Chieh Lee, Akiko Takahata, Sheau-Long Lee, Chia-Chao Wu, David J. Nikolic-Paterson, Shuk-Man Ka, Ann Chen 205(1) 202 212 0
2020 Phagocytosis enhancement, endotoxin tolerance, and signal mechanisms of immunologically active glucuronoxylomannan from Auricularia auricula-judae SCI International Journal of Biological Macromolecules Namal Perera Feng-Ling Yang, Hsiao-Wen Chiu, Chih-Yu Hsieh, Lan-Hui Li, Yan-Long Zhang, Kuo-Feng Hua, Shih-Hsiung Wu in press 0 0 0
2020 Synthetic 4-hydroxy auxarconjugatin B, a novel autophagy inducer, attenuates gouty inflammation by inhibiting the NLRP3 inflammasome SCI Cells Chih-Yu Hsieh Lan-Hui Li, Yulin Lam, Zhanxiong Fang, Chin Heng Gan, Yerra Koteswara Rao, Hsiao-Wen Chiu, Wei-Ting Wong, Tz-Chuen Ju, Fang-Hsin Chen, Oleg V. Chernikov, May-Lan Liu, Chung-Hua Hsu, Kuo-Feng Hua 9 279 0 0
2020 The long non-coding RNAs: paramount regulators of the NLRP3 inflammasome SCI Frontiers in Immunology Mridula Prakash Menon Kuo-Feng Hua in press 0 0 0
2020 Tris DBA Ameliorates Accelerated and Severe Lupus Nephritis in Mice by Activating Regulatory T Cells and Autophagy and Inhibiting the NLRP3 Inflammasome SCI Journal of Immunology Chung-Yao Wu Kuo-Feng Hua, Ching-Liang Chu, Shin-Ruen Yang, Jack L. Arbiser, Sung-Sen Yang, Yu-Chuan Lin, Feng-Cheng Liu, Shun-Min Yang, Shuk-Man Ka, Chen Ann 204(6) 1448 1461 13
2020 Tris DBA ameliorates IgA nephropathy by blunting the activating signal of NLRP3 inflammasome through SIRT1- and SIRT3-mediated autophagy induction SCI Journal of Cellular and Molecular Medicine Chung-Yao Wu Kuo-Feng Hua, Shin-Ruen Yang, Yi-Shan Tsai, Chih-Yu Hsieh, Chia-Chao Wu, Jia-Feng Chang, Jack L. Arbiser, Chiz-Tzung Chang, Ann Chen*, Shuk-Man Ka*. in press 0 0 0
2020 Xenon blunts NF-κB/NLRP3 inflammasome activation and improves acute onset of accelerated and severe lupus nephritis in mice SCI Kidney International Shin-Ruen Yang Kuo-Feng Hua, Lichieh Julie Chu, Yeu-Kuang Hwu, Shun-Min Yang, Chung-Yao Wu, Tsai-Jung Lin, Jui-Chun Weng, Hailin Zhao, Wan-Han Hsu, Feng-Cheng Liu, Wen-Jinn Liaw, Daqing Ma, Shuk-Man Ka, Ann Chen 1 0 0 0
2019 Accelerated and severe lupus nephritis benefits from M1, an active metabolite of ginsenoside, by regulating NLRP3 inflammasome and T cell functions in mice SCI Frontiers in Immunology Tsai-Jung Lin Chung-Yao Wu, Pei-Yi Tsai, Wan-Han Hsu, Kuo-Feng Hua, Ching-Liang Chu, Yu-Chieh Lee, Ann Chen, Sheau-Long Lee, Yi-Jin Lin, Chih-Yu Hsieh, Shin-Ruen Yang, Feng-Cheng Liu, Shuk-Man Ka 10 1951 0 0
2019 Activity Dependence of a Novel Lectin Family on Structure and Carbohydrate-Binding Properties SCI Molecules Irina Chikalovets Alina Filshtein, Valentina Molchanova, Tatyana Mizgina, Pavel Lukyanov, Olga Nedashkovskaya, Kuo-Feng Hua, Oleg Chernikov 25(1) 150 0 0
2019 Bacillus licheniformis-Fermented Products Reduce Diarrhea Incidence and Alter the Fecal Microbiota Community in Weaning Piglets SCI Animals De-Yu Hung Yeong-Hsiang Cheng, Wei-Jung Chen, Kuo-Feng Hua, Arkadiusz Pietruszka, Andrzej Dybus, Chuan-Shun Lin, Yu-Hsiang Yu 9 1145 0 0
2019 Glucosamine inhibits IL-1β expression by preserving mitochondrial integrity and disrupting assembly of the NLRP3 inflammasome. SCI Scientific Reports Hsiao-Wen Chiu Lan-Hui Li, Chih-Yu Hsieh, Yerra Koteswara Rao, Fang-Hsin Chen, Ann Chen, Shuk-Man Ka, Kuo-Feng Hua 9(1) 5603 0 0
2019 Mechanistic insight into the activation of the NLRP3 inflammasome by Neisseria gonorrhoeae in macrophages SCI Frontiers in Immunology Lan-Hui Li Jia-Sing Lin, Hsiao-Wen Chiu, Wen-Yu Lin, Tz-Chuen Ju, Fang-Hsin Chen, Oleg V. Chernikov, May-Lan Liu, Jen-Che Chang, Chung-Hua Hsu, Ann Chen, Shuk-Man Ka, Hong-Wei Gao, Kuo-Feng Hua 10 1815 0 0
2019 Mechanistic insight into the attenuation of gouty inflammation by Taiwanese green propolis via inhibition of the NLRP3 inflammasome SCI Journal of Cellular Physiology Chih-Yu Hsieh Lan-Hui Li, Yerra Koteswara Rao, Tz-Chuen Ju, Yu-Shin Nai, Yue-Wen Chen, Kuo-Feng Hua 234(4) 4081 4094 13
2019 Synthesis of the trisaccharide repeating unit of capsular polysaccharide from Klebsiella pneumonia SCI Tetrahedron Letters Woen Susanto Kah-Hoe Kong, Kuo-Feng Hua, Shih-Hsiung Wu, Yulin Lam 60(3) 288 291 3
2018 Affinity-driven Covalent Modulator of Glyceraldehyde-3-phosphate Dehydrogenase (GAPDH) Cascade SCI Angewandte Chemie International Edition in English Jeffy Chern Chun-Ping Lu, Zhanxiong Fang, Ching-Ming Chang, Kuo-Feng Hua, Yi-Ting Chen, Cheng Yang Ng, Yi-Lin Sophia Chen, Yulin Lam, Shih-Hsiung Wu 57(24) 7040 7045 5
2018 Antrodia cinnamomea Galactomannan Elicits Immunostimulatory Activity Through Toll-like receptor 4 SCI International Journal of Biological Sciences Namal Perera Feng-Ling Yang, Yueh-Tung Lu, Lan-Hui Li, Kuo-Feng Hua, Shih-Hsiung Wu 14(10) 1378 1388 10
2018 Carboxylic and O-acetyl moieties are essential for the immunostimulatory activity of glucuronoxylomannan: a novel TLR4 specific immunostimulator from Auricularia auricula-judae SCI Chemical Communications Namal Perera Feng-Ling Yang, Jeffy Chern, Hsiao-Wen Chiu, Chih-Yu Hsieh, Lan-Hui Li, Yan-Long Zhang, Kuo-Feng Hua, Shih-Hsiung Wu 54(51) 6995 6998 3
2018 Ergosterol peroxide from marine fungus Phoma sp. induces ROS-dependent apoptosis and autophagy in human lung adenocarcinoma cells. SCI Scientific Reports Han-Ying Wu Feng-Ling Yang, Lan-Hui Li, Yerra Koteswara Rao, Tz-Chuen Ju, Wei-Ting Wong, Chih-Yu Hsieh, Michael V. Pivkin, Kuo-Feng Hua, Shih-Hsiung Wu 8(1) 17956 0 0
2018 Improvement of hyperglycemia in a murine model of insulin resistance and high glucose- and inflammasome-mediated IL-1β expressions in macrophages by silymarin SCI Chemico-Biological Interactions Chun-Ping Lu Chien-Yu Huang, Szu-Hsuan Wang, Chih-Hsien Chiu, Lan-Hui Li, Kuo-Feng Hua, Tzu-Hua Wu 290 12 18 6
2018 Repositioning of the β-blocker carvedilol as a novel autophagy inducer that inhibits the NLRP3 inflammasome SCI Frontiers in Immunology Wei-Ting Wong Lan-Hui Li, Yerra Koteswara Rao, Shih-Ping Yang, Shu-Meng Cheng, Wen-Yu Lin, Cheng-Chung Cheng, Ann Chen, Kuo-Feng Hua 9 1920 0 0
2013 Antroquinonol mitigates accelerated and progressive IgA nephropathy model in mice via activating NrF2 pathway, and inhibiting T cells and NLRP3 inflammasome SCI Free Radic Biol Med,61C 花國鋒 Shun-Min Yang, Shuk-Man Ka, Kuo-Feng Hua, Tzu-Hua Wu, Yi-Ping Chuang, Ya-Wen Lin, Feng-Ling Yang, Shih-Hsiung Wu, Sung-Sen Yang, Shih-Hua Lin, Jia-Ming Chang, Ann Chen 285 297
2013 Bamboo vinegar decreases inflammatory mediator expression and NLRP3 inflammasome activation by inhibiting reactive oxygen species generation and protein kinase C-alpha/delta activation SCI PLoS ONE 花國鋒 Chen-Lung Ho, Chai-Yi Lin, Shuk-Man Ka, Ann Chen, Yu-Ling Tasi, May-Lan Liu, Yi-Chich Chiu, Kuo-Feng Hua vol. 8, no. 10
2013 Citral is renoprotective for focal segmental glomerulosclerosis by inhibiting oxidative stress and apoptosis and activating Nrf2 pathway in mice. SCI PLoS ONE 花國鋒 Shun-Min Yang, Kuo-Feng Hua, Yu-Chuan Lin, Ann Chen, Jia-Ming Chang, Louis Kuoping Chao, Chen-Lung Ho, Shuk-Man Ka vol. 8, no. 9
2013 Generation of reactive oxygen species by polyenylpyrroles derivatives causes DNA damage leading to G2/M arrest and apoptosis in human oral squamous cell carcinoma cells SCI PLoS ONE 花國鋒 Kuo-Feng Hua, Pei-Chun Liao, Zhanxiong Fang, Feng-Ling Yang, Yu-Liang Yang, Yi-Lin Chen, Yi-Chich Chiu, May-Lan Liu, Yulin Lam, Shih-Hsiung Wu vol. 8, no. 6
2013 Lipopolysaccharide/adenosine triphosphate-mediated signal transduction in the regulation of NLRP3 protein expression and caspase-1-mediated interleukin-1β secretion SCI Inflammation Research 花國鋒 Pei-Chun Liao, Louis Kuoping Chao, Ju-Ching Chou, Wei-Chih Dong, Chien-Nan Lin, Chai-Yi Lin, Ann Chen, Shuk-Man Ka, Chen-Lung Ho, Kuo-Feng Hua vol.62,no.1 89 96
2013 Osthole mitigates progressive IgA nephropathy by inhibiting reactive oxygen species generation and NF-kB/NLRP3 pathway SCI PLoS ONE 花國鋒 Kuo-Feng Hua, Shun-Min Yang, Tzu-Yang Kao, Jia-Ming Chang, Hui-Ling Chen, Sung-Sen Yang, Louis Kuoping Chao, Ann Chen, Shuk-Man Ka
2013 Polyenylpyrrole derivatives inhibit NLRP3 inflammasome activation and inflammatory mediator expression through reduction of reactive oxygen species production and mitogen-activated protein kinase activation SCI PLoS ONE 花國鋒 Kuo-Feng Hua, Ju-Ching Chou, Yulin Lam, Yu-Ling Tasi, Ann Chen, Shuk-Man Ka, Zhanxiong Fang, May-Lan Liu, Feng-Ling Yang, Yu-Liang Yang, Yi-Chich Chiu, Shih-Hsiung Wu vol. 8, no. 10
2012 Composition and Antipathogenic Activities of the Twig Essential Oil of Chamaecyparis formosensis from Taiwan SCI Natural Product Communications 花國鋒 Chen-Lung Ho, Kuo-Feng Hua, Kuan-Ping Hsu, Eugene I-Chen Wang, Yu-Chang Su vol.7,no7 933 936
2012 Freshwater Clam Extract Inhibits Inflammatory Responses in LPS-activated Macrophages by Reducing the Activation of Mitogen-activated Protein Kinases and NF-κB SCI Natural Product Communications 花國鋒 Kuo-Feng Hua, Guan-Ming Chen, Chen-Lung Hob, Ming-Chung Chena, Yi-Ling Chena, Wei-Jung Chena, Jeng-Fang Huangc, Yuan-Shing Perngd, Chai-Ching Lin vol.7,no.11 1435 1440
2012 High glucose increases nitric oxide generation in lipopolysaccharide-activated macrophages by enhancing activity of protein kinase C-alpha/delta and NF-kB SCI Inflammation Research 花國鋒 Kuo-Feng Hua, Szu-Hsuan Wang, Wei-Chih Dong, Chai-Yi Lin, Chen-Lung Ho, Tzu-Hua Wu vol.61,no10 1107 1116
2012 Oligosaccharide and Peptidoglycan of Ganoderma lucidum Activate the Immune Response in Human Mononuclear Cells SCI Journal of Agricultural and Food Chemistry 花國鋒 Chia-Che Tsai, Feng-Ling Yang, Zih-You Huang, Chien-Sheng Chen, Yu-Liang Yang, Kuo-Feng Hua, Jianjun Li, Shui-Tein Chen, and Shih-Hsiung Wu vol.60,no11 2830 2837
2011 A novel exopolysaccharide from the biofilm of Thermus aquaticus YT-1 induces the immune response through Toll-like receptor 2 SCI Journal of Biological Chemistry 花國鋒 Miao-Hsia Lin, Yu-Liang Yang, Yen-Po Chen, Kuo-Feng Hua, Chun-Ping Lu, Fuu Sheu, Guang-Huey Lin, San-San Tsay, Shu-Mei Liang, Shih-Hsiung Wu vol.286,no20 17736 17745
2011 Epigallocatechin-3-gallate prevents lupus nephritis development in mice via enhancing the Nrf2 antioxidant pathway and inhibiting NLRP3 inflammasome activation SCI Free Radical Biology & Medicine 花國鋒 Pei-Yi Tsai, Shuk-Man Ka, Jia-Ming Chang, Hsiang-Cheng Chen, Hao-Ai Shui, Chen-Yun Li, Kuo-Feng Hua, Wen-Liang Chang, Jiann-Jyh Huang, Sung-Sen Yang, Ann Chen vol.51,no3 744 754
2011 Honokiol inhibits LPS-induced maturation and inflammatory response of human monocyte-derived dendritic cells SCI Journal of Cellular Physiology 花國鋒 Chia-Yang Li, Louis Kuoping Chao, Shu-Chi Wang, Min-Lung Tsai, Hon-Zu Chang, Shih-Hua Fang, Pei-Chun Liao, Chen-Lung Ho, Shui-Tein Chen, Wei-Chung Cheng, Chi-Shiun Chiang, Yueh-Hsiung Kuo, Kuo-Feng Hua, Ian C. Hsu vol.262,no9 2338 2349
2011 Structure and immunological characterization of the capsular polysaccharide of a pyrogenic liver abscess Klebsiella pneumoniae: activation of macrophages through Toll-like receptor 4 SCI Journal of Biological Chemistry 花國鋒 Feng-Ling Yang, Yu-Liang Yang, Pei-Chun Liao, Ju-Ching Chou, Keng-Chang Tsai, An-Suei Yang, Fuu Sheu, Tzu-Lung Lin, Pei-Fang Hsieh, Jin-Town Wang, Kuo-Feng Hua, Shih-Hsiung Wu vol.286,no24 21041 21051
2010 Anti-inflammatory bioactivities of honokiol through inhibition of protein kinase C, mitogen-activated protein kinase, and the NF-kB pathway to reduce LPS-induced TNF-alpha and NO expression SCI Journal of Agricultural and Food Chemistry 花國鋒 Louis Kuoping Chao, Pei-Chun Liao, Chen-Lung Ho, Eugene I-Chen Wang, Chao-Chin Chuang, Huan-Wen Chiu, Lang-Bang Hung, Kuo-Feng Hua vol.58,no.6 3472 3478
2010 Binding and cleavage of E. coli Hua by the E. SCI coli Lon,Biophysical Journal 花國鋒 Jiahn-Haur Liao, Yu-Ching Lin, Jowey Hsu, Alan Yueh-Luen Lee, Tse-An Chen, Chun-Hua Hsu, Jiun-Ly Chir, Kuo-Feng Hua, Tzu-Hua Wu, Li-Jenn Hong, Pei-Wen Yen, Arthur Chiou, Shih-Hsiung Wu vol.98,no.1 129 137
2010 Immunostimulatory bioactivity of algal polysaccharides from Chlorella pyrenoidosa activates macrophages via Toll-like receptor 4 SCI Journal of Agricultural and Food Chemistry 花國鋒 Hsien-Yeh Hsu, Narumon Jeyashoke, Chin-His Yeh, Yuan-Jaw Song, Kuo-Feng Hua, Louis Kuoping Chao vol.58,no.2 927 936
2010 Osthole regulates inflammatory mediator expression through modulating NF-kB, mitogen-activated protein kinases, protein kinase C, and reactive oxygen species SCI Journal of Agricultural and Food Chemistry 花國鋒 Pei-Chun Liao, Shin-Chang Chien, Chen-Lung Ho, Eugene I-Chen Wang, Shu-Ching Lee, Yueh-Hsiung Kuo, Narumon Jeyashoke, Jie Chen, Wei-Chih Dong, Louis Kuoping Chao, Kuo-Feng Hua vol.58,no19 10445 10451
2010 Synthesis and biological evaluation of polyenylpyrrole derivatives as anti-cancer agents acting through caspases-dependent apoptosis SCI Journal of Medicinal Chemistry 花國鋒 Zhanxiong Fang, Pei-Chun Liao, Yu-Liang Yang, Feng-Ling Yang, Yi-Ling Chen, Yulin Lam*, Kuo-Feng Hua, Shih-Hsiung Wu vol.53,no22 7967 7978
西元年度 計畫名稱 主持人 工作職稱 共同(協同)主持人 委託/補助機構 計畫開始日 計畫結束日 語言 相關網址
2020 探討肉桂醛與肉桂醛衍生物用於調節NLRP3發炎體及改善發炎性腸道疾病及痛風性發炎之功效與作用機轉(2/3) 花國鋒 主持人 - 科技部 2020/08/01 2021/07/31
2020 浩峰一號對亨廷頓舞蹈症小鼠之影響 花國鋒 主持人 浩峰生物科技股份有限公司 2020/04/01 2021/03/31
2020 浩峰一號對腸道發炎疾病小鼠之影響 花國鋒 主持人 浩峰生物科技股份有限公司 2020/04/01 2021/03/31
2019 探討肉桂醛與肉桂醛衍生物用於調節NLRP3發炎體及改善發炎性腸道疾病及痛風性發炎之功效與作用機轉(1/3) 花國鋒 主持人 科技部 2019/08/01 2020/07/31
2019 益生菌產製與人工合成抗菌胜肽於禽畜及伴侶動物保健用飼料添加物之功能驗證與開發-益生菌產製與人工合成抗菌胜肽於禽畜及伴侶動物保健用飼料添加物之功能驗證與開發(2/2) 花國鋒 主持人 武敬和、游玉祥 科技部 2019/06/01 2020/05/31
2019 臺俄(RU)雙邊協議型擴充加值(add-on) 國際合作研究計畫-探討柳珊瑚多醣化學結構及NLRP3發炎體抑制活性(1/3) 花國鋒 主持人 科技部 2019/01/01 2021/12/31
2018 Identification and therapeutic approach of NLRP3 inflammasome inhibitors to treat diseases associated with neuroinflammation 花國鋒 主持人 安成生物科技股份有限公司 2018/12/01 2019/11/30
2018 LCHK168 對亨廷頓舞蹈症小鼠之影響 花國鋒 主持人 匯德生物科技股份有限公司 2018/10/01 2019/09/30
2018 LCHK168 對人類口腔癌之毒殺作用及作用機轉 花國鋒 主持人 匯德生物科技股份有限公司 2018/10/01 2019/09/30
2018 皿培牛樟芝生產技術改進及抗發炎活性之探討 花國鋒 主持人 睿森生物科技有限公司 2018/05/01 2018/10/31
2018 益生菌產製與人工合成抗菌胜肽於禽畜及伴侶動物保健用飼料添加物之功能驗證與開發-益生菌產製與人工合成抗菌胜肽於禽畜及伴侶動物保健用飼料添加物之功能驗證與開發(1/2) 鄭永祥 共同主持人 武敬和、花國鋒、游玉祥 科技部 2018/06/01 2019/05/31
2018 評估人蔘皂甙衍生物CLA-LCHK-168抑制NLRP3發炎體的效果 花國鋒 主持人 匯德生物科技股份有限公司 2018/05/01 2018/10/31
2017 HE-07Fr4對IgA腎炎小鼠腎臟纖維化及巨噬細胞NLRP3發炎體活化之影響 花國鋒 主持人 財團法人工業技術研究院 2017/05/12 2017/08/31
2017 以小鼠疾病模式探討人蔘皂苷預防與改善痛風性發炎之功效 花國鋒 主持人 匯德生物科技股份有限公司 2017/10/01 2018/09/30
2017 建置一台英雙方研究O-linked N-乙醯葡萄糖胺修飾蛋白調控NLRP3發炎體之整合型平台 ( 2 / 2 ) 花國鋒 主持人 吳世雄 羅禮強 朱俐潔 李佳陽 陳安 科技部 2017/04/01 2018/03/31
2017 牛樟芝產品提升免疫細胞殺菌功能之探討 花國鋒 主持人 睿森生物科技有限公司 2017/05/01 2017/10/31
2017 評估乙烯吡咯衍生物用於預防與改善痛風性發炎的可能性 花國鋒 主持人 匯德生物科技股份有限公司 2017/06/16 2017/11/15
2017 評估人蔘皂甙預防與改善痛風性發炎的效果 花國鋒 主持人 匯德生物科技股份有限公司 2017/05/01 2017/10/31
2016 IgA腎炎小鼠的腎臟白血球浸潤與細胞激素分泌 花國鋒 主持人 工業技術研究所 2016/07/04 2016/12/26
2016 低耗能養殖池底水力迴轉清淤臂的研發 花國鋒 主持人 睿森生物科技有限公司 2016/05/01 2016/10/31
2016 利用NLRP3發炎體為主之疾病專一性分析平台驗證人蔘皂苷對慢性腎臟病與代謝疾病預防與改善之功效 花國鋒 主持人 朱俐潔 科技部 2016/08/01 2019/07/31
2016 建置一台英雙方研究O-linked N-乙醯葡萄糖胺修飾蛋白調控NLRP3發炎體之整合型平台 花國鋒 主持人 吳世雄、羅禮強、朱俐潔、朱清良李、佳陽 科技部 2016/04/01 2017/03/31
2016 驗證人蔘皂苷對亨廷頓舞蹈症預防與改善之功效 花國鋒 主持人 匯德生物科技股份有限公司 2016/10/01 2017/09/30
2015 人蔘皂甙衍生物毒性與活性測試 花國鋒 主持人 匯德生物科技股份有限公司 2015/04/24 2015/09/23
2015 探討固態發酵培養牛樟芝產品預防與改善痛風的效果 花國鋒 主持人 睿森生物科技有限公司 2015/05/01 2015/10/31
2015 驗證人蔘皂苷對痛風預防與改善之功效 花國鋒 主持人 匯德生物科技股份有限公司 2015/05/01 2016/04/30
2014 人蔘皂苷免疫調節活性試驗 花國鋒 主持人 匯德生物科技股份有限公司 2014/05/01 2015/04/30
2014 台俄國合計畫-海洋天然物醫藥保健產品開發之合作交流平台 花國鋒 主持人 行政院國家科學委員會 2014/01/01 2016/12/31
2014 開發及生產行銷高經濟機能性生技產品(專案) 花國鋒 主持人 匯德生物科技股份有限公司 2014/05/01 2014/10/31
2014 開發及生產行銷高經濟機能性生技產品(專案) 花國鋒 主持人 睿森生物科技有限公司 2014/05/01 2014/10/31
2013 寶石珊瑚萃取物生技保養品之開發 邱奕志 協同主持人 陳怡伶、羅祺祥、花國鋒、曹博宏 明麗生技股份有限公司 2013/01/01 2013/12/31
2013 竹醋液與其活性成分在發炎與代謝相關疾病預防及改善之應用 花國鋒 主持人 行政院國家科學委員會 2013/08/01 2016/07/31
2012 新穎陽離子抗菌胜(宿主防禦胜)之抗菌、抗癌與抗發炎機制探討 陳威戎 共同主持人 陳怡伶、花國鋒 行政院國家科學委員會 2012/08/01 2013/07/31
2011 開發肉桂醛為預防發炎之保健產品與治療發炎相關疾病之輔助製劑 花國鋒 主持人 行政院國家科學委員會 2011/08/01 2012/07/31
2009 肝膿瘍性克雷伯氏肺炎桿菌莢膜多醣體結構與功能性分析 花國鋒 主持人 行政院國家科學委員會 2009/02/01 2010/07/31